Keshan disease definition of keshan disease by medical. Is selenium deficiency really the cause of keshan disease. Host nutritional status and its effect on a viral pathogen. Keshan disease herbal treatment, prevention, symptoms. Summary of notifiable diseases united states, 2011. These symptoms were later found prevalent in a wide belt extending from northeast to southwest china, all due to selenium. Selenium deficiency and cardiomyopathy tsung o cheng, 2002. Kashinbeck disease results in atrophy, degeneration, and necrosis of cartilage tissue in the joints. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of. As one of several types of nutritional diseases, keshan disease is unique in that it primarily affects young women and children.
It seems to be found in individual in areas where the level of selenium in the soil is low. Kashinbeck disease definition of kashinbeck disease by. Keshan disease kd is a potentially fatal form of cardiomyopathy disease of the heart muscle endemic in certain areas of china. Southeast siberia and north korea are other affected areas. Symptoms of keshans disease health conditions vital. Observations on effect of sodium selenite in prevention of keshan disease. If you have problems viewing pdf files, download the latest version of adobe reader for language access assistance, contact the ncats public information officer genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Overview of keshan disease as a medical condition including introduction, prevalence, prognosis, profile, symptoms, diagnosis, misdiagnosis, and treatment. The incidence of the disease was dramatically reduced after the population was supplemented with sodium selenite. Browse the gard list of rare diseases and related terms to find topics of interest to you. Keshan disease genetic and rare diseases information center.
Apr 08, 2020 keshan disease kd is a lifethreatening condition that affects the heart muscle. Adobe acrobat dc gives you everything you need to easily create, edit, share, and sign pdf documents from anywhere. Women of childbearing age and children were its primary victims. Keshan s disease keshan s disease heart gets bigger to increase surface area to catch selenium, pushes ribs out creating barrel chest, only found in china. The icd code e59 is used to code keshan disease keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang province, northeast china, where symptoms were first noted.
Keshan disease is an endemic cardiomyopathy found in keshan, northeast china. Selenium toxicity and links between deficiency and keshan disease and kashinbeck disease are described. Despite the strong evidence that selenium deficiency is a fundamental factor in keshan s disease, it is seasonal and the cause is a virus that produces inflammation of the heart. Selenium deficiency also contributes to kashinbeck disease. The heart disorder that is caused by selenium deficiency is keshan disease. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in. Risk factors for keshans disease health conditions. Keshan disease was first discovered in keshan a province in china. Keshan disease and mitochondrial cardiomyopathy springerlink. The main risk factor which causes keshan s disease is a deficiency of selenium in the diet, due either to not eating foods rich in selenium or in living in an area where there is little selenium in the soil and this contributes heavily on whether or not there is adequate intake of selenium in the diet. Keshan disease genetic and rare diseases information. Here, we used stepwise multiple regression analysis to analyze the risk factors of the disease and the main. Pdf selenium is an essential element for humans, animals and some species of microorganisms.
Caused by deficiency of selenium in the diet, enlarged heart and poor heart function selenium deficiency source diseases database. At the time, nobody understood the cause of this disease, so it was called keshan disease. Keshan disease is a potentially fatal disease of the heart. It was later found to be prevalent in a wide belt extending from southwest to northeast china. Nutritional factors that may be protective against cancer include. Soil can affect human health in several ways leading either to specific diseases or to more general ill health. Antiepidemic station of sichuan province, chengdu, antiepidemic station of xichang district, sichuan, and antiepidemic station of mianning county, sichuan. Advertisement it has also been suggested that keshan s disease may be, at least partly due to infection by a virus coxsackievirus b3 cvb30, which would initially present with the typical viral infection symptoms such as. Keshan heart disease university of medicine and dentistry. The icd code e59 is used to code keshan disease keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang. In addition, an individual can experience eczema, arthritis, cataracts and infections. Unless otherwise noted, the data are final totals for 2011 reported as of june 30, 2012.
It is found in the soil and in marine bivalves such as oysters. Oxidative stress is involved in the pathogenesis of keshan disease. Keshan disease kd is a lifethreatening condition that affects the heart muscle. Keshan disease research group institute of health chinese academy of medical sciences beijing, the peoples republic of china search for more papers by this author first published. Keshan disease research group of chinese academy of medical sciences.
Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. Keshan disease is a disease of heart muscle congestive cardiomyopathy which is potentially fatal. Keshan disease kd is an endemic cardiomyopathy of unknown cause and is named after keshan county in heilongjiang. Keshan disease uncountable a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus.
The main symptom of keshan disease is myocardial necrosis, leading to weakening of the heart. These symptoms were found prevalent in a wide belt extending from northeast to southwest china, all due to seleniumdeficient soil. Selenium and keshan disease the new york academy of. In asia and africa, dietary selenium deficiency is associated with a cardiomyopathy known as keshan disease and an osteoarthropathy called kashinbeck disease.
Keshan disease is a congestive cardiomyopathy probably caused by dietary deficiency of selenium, named after keshan, where symptoms were first noted. Margaret rayman1 briefly mentions the relation of selenium with keshan disease, a dilated cardiomyopathy that is endemic in seleniumdeficient areas and is responsive to selenium supplements. Particularly cruel, the disease frequently occurred without warning and led to the death of a large number of people. Department of epidemiology and environmental health, juntendo university school of medicine, 211 hongo, bunkyoku, tokyo 18421, japan. It is named for the northeastern chinese county keshan, where the disease prevalence is high because of seleniumdeficient soil.
Jan alexander, in handbook on the toxicology of metals fourth edition, 2015. Learn vocabulary, terms, and more with flashcards, games, and other study tools. These symptoms were later found prevalent in a wide belt extending from northeast to southwest china, all due to seleniumdeficient soil. Jul 01, 2019 if children and adolescents dont get enough selenium, they could develop keshan disease and kashinbeck disease, two conditions that can affect the heart, bones, and joints. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in the soil is low. Convert html to pdf online in the browser or in your php, python, ruby. Selenium deficiency and viral infection the journal of. Keshan disease herbal treatment, prevention, symptoms, causes. While individuals who are diagnosed with a selenium deficiency and receive selenium supplements have been able to see some improvement in the continuing development of the disease, however, it can not reserve any of the heart muscle damage that has already occurred. This list includes the main name for each condition, as well as alternate names. The body also becomes more susceptible to illness caused by other nutritional.
Risk factors for keshans disease health conditions vital. Research the causes of these diseases that are similar to, or related to, keshan disease. Disease description generator this description generator will generate a fairly random description of a disease, including its symptoms, cause, treatment, and rarity. Kashinbeck disease expanding the spectrum of iodinedeficiency disorders selenium, as selenocysteine, is an integral component of two important enzymes glutathione peroxidase and iodothyronine deiodinase that are present in many tissues, including the thyroid gland. It is caused by a selenium deficiency and is characterized by pulmonary edema and heart failure. To research the causes of keshan disease, consider researching the causes of these these diseases that may be similar, or associated with keshan disease.
Screening of tissues from keshan disease victims revealed the presence of a number of viruses, including coxsackieviruses 2. From 1984 to 1986, a national comprehensive scientific investigation on kd in chuxiong region of yunnan province in the southwest china was conducted. Disease description generator fantasy name generators. Symptoms of keshan disease include weakness of muscle in this organ, making it abnormally large. Keshan disease is a potentially fatal form of cardiomyopathy disease of the heart muscle. Institute of health, chinese academy of medical sciences.
Keshan disease kd is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. Investigation of a muscle disease in animals and a cluster of cases of cardiomyopathy in a region of china led to the elucidation of a central role for selenoproteins in human health. Selenium is an essential mineral required by the body. Named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. Adoption nutritionselenium deficiency keshan disease.
Scientists in china noted that keshan disease had a seasonal and annual incidence that was more characteristic of an infectious disease than one caused by a nutrient deficiency. Inclusion on this list does not serve as official recognition by the nih that a disease is rare. Keshan disease is a cardiomyopathy endemic in children and pregnant women who live in the keshan region of china, where selenium levels in food are extremely low chen et al. A fatal heart disease first reported in keshan county of the greater metropolitan qiqihar of the heilongjiang province, mainland china, which affects children and young women. In any case, while still investigating the cause of keshan disease and the.
These symptoms were later found prevalent in young women and children in a wide belt extending from northeast to southwest china, a region with a seleniumdeficient soil. The incidence of the disease was dramatically reduced after the population was supplemented. Damage to this organ can be specifically detected by rising levels of troponin i and troponin t. This organs foramen ovale closes immediately after birth, as it is among two fetal shunts that bypass the lungs to bring blood here. It was first noted in the keshan province in heilongjiang, china. Jun 24, 2010 keshan disease kd is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. The population grows its own food on these soils and does not eat food from other regions. Tibet currently has the highest incidence rate of kbd in china.
Summary of notifiable diseases united states, 2011 please. Which of the following fruits is likely to be the best source of vitamin a. In 1935, a terrible disease was spreading wantonly in some rural areas of heilongjiang province in northeastern china. In i935, a terrible disease was spreading wantonly in some rural areas of heilongjiang province in northeastern china.
Keshan disease selenium for treatment of keshan disease. Keshan disease, selenium deficiency, and the selenoproteome. Convert html to pdf online, webhtml to pdf api pdfcrowd. The prevalence of keshan disease in china international journal. It is hard to consider keshan disease preventable because the only way to ensure that the individual is getting enough selenium would be to test the soil in the area.
As with all description generators on this site, the overall structure will remain the same, but the details are always randomized. Some conditions that are not considered rare are on this list and are labeled. Keshan disease prevalent status surveillance in chuxiong. Kashinbeck disease expanding the spectrum of iodine. Morphologically, the condition is characterized by multifocal necrosis and replacement fibrosis of the myocardium, resulting in acute or chronic heart failure. They are some parts of the united states that have low levels of selenium. Dec 04, 2018 home medterms medical dictionary az list disease, keshan definition medical definition of disease, keshan medical author. Kashinbeck disease kbd is a chronic, endemic type of osteochondropathy disease of the bone that is mainly distributed from northeastern to southwestern china, including 15 provinces. Chronic selenium deficiency may also occur in individuals with malabsorption and long term seleniumdeficient parenteral nutrition. Fulminant heart failure due to selenium deficiency. Keshan disease is an endemic cardiomyopathy in china. Yang institute of health, chinese academy of medical sciences, beijing, peoples republic of china keshan disease is an endemic cardiomyopathy which was first observed in keshan county, heilonjiang province, northeast china. A condition caused by deficiency of the essential mineral selenium.
As one of several types of nutritional diseases, keshan disease is unique in that it. In bureau of endemic disease prevention and control of the ministry of health, editor. Selenium in human nutrition was the theme of the 1986 research workshop of the american society for parenteral and enteral nutrition. Selenium supplements has been found to protect people from developing keshan disease but cannot reverse heart muscle damage once it occurs. If keshan s disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency. Some illnesses are caused by peoples eating soil geophagia, or by their inhaling it which can lead to malignancy if the soil contains asbestiform minerals.